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Article: Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons.

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Voisin AN; Mnie-Filali O; Giguère N; Fortin GM; Vigneault E; El Mestikawy S; Descarries L; Trudeau LÉ
Front Neuroanat, 2016


The structural features of SERT immunoreactive axon terminals in the striatum of immature (P15) and mature (P60–70), VGLUT3 KO mice are unaltered.

Dimensions
n No. Mean diameter (μm) Area (μm2) Mitochondria (%)
P15
WT 5 157 0.51 ± 0.04 0.17 ± 0.02 19.1 ± 2.1
KO 5 129 0.57 ± 0.03 0.2 ± 0.02 20.95 ± 3.6
P60
WT 5 157 0.47 ± 0.03 0.14 ± 0.01 26.85 ± 6.2
KO 5 152 0.47 ± 0.01 0.14 ± 0.002 29.51 ± 2.3

The table provides the mean diameter and the area of SERT-positive axon terminals detected in striatal thin sections. The proportion of terminals containing mitochondria was also calculated. Data are expressed as means ± SEM. n, number of mice; No., number of axon terminals examined.


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